Leadership

Brian Culley

Mr. Culley joined Lineage as Chief Executive Officer in September 2018 and served as Interim Chief Financial Officer from January 20, 2021 to June 21, 2021 and from July 8, 2022 to November 14, 2022. Prior to joining Lineage, Mr. Culley served from August 2017 to September 2018 as interim Chief Executive Officer at Artemis Therapeutics, Inc. (ATMS). Mr. Culley previously served as Chief Executive Officer of Mast Therapeutics, Inc. (MSTX), from 2010, and was also a member of its board of directors from 2011, until Mast’s merger with Savara, Inc. (SVRA) in April 2017. Mr. Culley served from 2007 to 2010 as Mast’s Chief Business Officer and Senior Vice President, from 2006 to 2007 as Mast’s Senior Vice President, Business Development, and from 2004 to 2006 as Mast’s Vice President, Business Development. From 2002 until 2004, Mr. Culley was Director of Business Development and Marketing for Immusol, Inc. From 1999 until 2000, he worked at the University of California, San Diego (UCSD) Department of Technology Transfer & Intellectual Property Services and from 1996 to 1999 he conducted drug development research for Neurocrine Biosciences, Inc. (NBIX). Mr. Culley served on the Board of Orphagen Pharmaceuticals, Inc. from May 2017 until December 2022. Mr. Culley has more than 30 years of business and scientific experience in the life sciences industry. He received a B.S. in biology from Boston College, a masters in biochemistry and molecular biology from the University of California, Santa Barbara, and an M.B.A. from The Johnson School of Business at Cornell University. Mr. Culley brings to our Board significant knowledge of the biotechnology industry and extensive experience as an executive and board member of publicly traded pharmaceutical companies.

Jill Howe

Ms. Howe joined Lineage as Chief Financial Officer on November 14, 2022. Before joining Lineage, Ms. Howe most recently served as the Chief Financial Officer of DTx Pharma, Inc., a biotechnology company, a position she held from June 2021 through July 2022. Prior to joining DTx Pharma, from January 2018 to June 2021, Ms. Howe served as Vice President of Finance and Treasurer for Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company. Prior to Gossamer Bio, she served as Controller & Director of Finance of Amplyx Pharmaceuticals, Inc., a biopharmaceutical company, from March 2016 to December 2017. She previously held positions, including as Controller and Director of Finance, at Receptos, Inc., a biotechnology company, and at Somaxon Pharmaceuticals, Inc., a specialty pharmaceutical company. Since October 2021, Ms. Howe has served on the board of directors of Codagenix Inc., and from November 2021 to March 2025, Ms. Howe served on the board of directors of, and as the chair of the audit committee and as a member of the nominating committee of, Biora Therapeutics, Inc. (Nasdaq: BIOR). Ms. Howe earned a B.S. in Accountancy from San Diego State University.

George A. Samuel III

Mr. Samuel joined Lineage as General Counsel and Corporate Secretary on September 1, 2021. Prior to joining Lineage, Mr. Samuel most recently served as Director, Senior Counsel for Lytx, Inc., where he managed the commercial legal operations for an international video telematics SaaS company, a position he held from January 2020 to August 2021. Prior to that, Mr. Samuel served as VP, General Counsel and Corporate Secretary for Cardiff Oncology, Inc. (formerly known as Trovagene, Inc.), a clinical-stage biotechnology company focused on developing treatments in oncology. In his career, he advised on strategic, business development and operational decisions; oversaw capital raising efforts, regulatory compliance as well as SEC reporting; and managed intellectual property, including technology transfer and licensing. Mr. Samuel has also practiced corporate law at Cooley LLP, DLA Piper LLP, and Winston & Strawn LLP, where he served as outside counsel to public and private companies in a variety of commercial transactions. Mr. Samuel received a J.D. from Columbia University School of Law, and a B.A. in Philosophy from Tufts University and is a member of the State Bar of California and New York

Priyantha Herath, M.D., Ph.D.

Dr. Herath joined Lineage as Senior Vice President & Head of Clinical in April 2026. He is a U.S. Board-certified specialist neurologist, with wide-ranging expertise in clinical development from early translational, first-in-human trials through to successful completion of multiple Phase III studies. Dr. Herath has broad clinical experience in neurodegenerative disorders, including Huntington’s Disease (HD), Parkinsonian Syndromes (PD, MSA, CBGD, PSP), Ataxias (SCA, FA), Alzheimer’s Disease, Frontotemporal Dementia, and others. He is an expert in cognitive neuroscience, stereotaxy, multi-modal brain imaging (quantitative Positron Emission Tomography (PET), high-field Magnetic Resonance Imaging (MRI), and Magnetic Resonance Spectroscopy (MRS), and fluid biomarkers.

Most recently, he served as Clinical Group Leader for the Myasthenia Gravis (MG) disease portfolio at Argenx, where he oversaw strategic clinical and regulatory development for several late-stage development programs, including leading and executing two successful Phase III clinical studies in SeroNegative MG and Ocular MG. Prior to Argenx, he was the Neurology Clinical Lead at Alnynlam Pharmaceuticals, leading the early clinical development of siRNA therapeutics programs in HD, SOD1-ALS, and other nascent central nervous system (CNS) siRNA programs. Before joining Alnylam, Dr. Herath served as Medical Director at Voyager Therapeutics, where he was clinical lead for their flagship HD program and several CNS AAV gene therapy programs in development. At Jazz Pharmaceuticals, he managed clinical trial execution of a Phase II Parkinson’s Disease program. He served as a Clinical Consultant to Alchemab, Inc., and other biotech companies, advising on the development of first in human CNS programs. Through this work, Dr. Herath has accumulated experience in clinical development and regulatory engagements with multiple national regulatory agencies across each stage of drug development.

Prior to Jazz, Dr. Herath was a Clinical Associate Professor of Neurology at the University of Kansas Medical Center, and at University of South Carolina School of Medicine, serving as an academic neurologist, combining patient care with medical research and teaching the next generation of neurologists. In his clinical capacity, Dr. Herath treated more than 20,000 patients with neurodegenerative diseases in varied phenotypes. Because of this direct patient care, he possesses a deep understanding of disease presentation, progression, and meaningful outcomes. In his clinical career, Dr. Herath also founded and served as Director of several multidisciplinary movement and Parkinson’s Disease and deep brain stimulation clinics, including at the Kansas City Veterans Affairs Medical Center, at the University of South Carolina School Of Medicine and at Baylor, Scott & White Medical Center Round Rock TX among others.

Dr. Herath received his M.D. with honors from the Faculty of Medicine, University of Peradeniya, Sri Lanka, and his Ph.D. in Neuroscience from the Karolinska Institutet. Early in his career, he served as a civilian combat trauma surgeon at the National Hospital (SJGH) of Sri Lanka, performing surgeries for blast trauma injuries due to landmines and caring for those patients, including with spinal cord injury. He was a visiting scholar at the Weizmann Institute of Science and the All India Institute of Medical Sciences. Following his Ph.D., Dr. Herath completed residencies in Neurology and Psychiatry at the University of Pittsburgh Medical Center. Subsequently, he also completed specialized training in Movement Disorders from the National Institute of Neurological Disorders and Stroke (NINDS/NIH) under the late Mark Hallett, M.D., and an additional Advanced Movement Disorders/DBS fellowship from the University of Maryland under the late William Weiner, M.D.. Dr. Herath is deeply committed to advancing meaningful and impactful treatments that address unmet medical needs and to improving the quality of life for those affected by debilitating conditions.

Derek Kelaita

Derek Kelaita joined Lineage Cell Therapeutics as the Vice President, Business Development in August 2019.  Derek brings 20 years of experience with publicly-traded and venture-backed biotechnology companies to Lineage.  He was most recently Vice President of Business Development at ArmaGen from 2013 through early 2019, where he negotiated several early-stage research collaborations and option agreements with pharma partners related to the company’s blood-brain barrier technology as well as a $225M global license agreement with Shire plc (now part of Takeda Pharmaceuticals) for ArmaGen’s lead clinical stage program.  Throughout his career, Derek is responsible for licensing/M&A transactions cumulatively valued at over $1 billion in multiple therapeutic areas including:  Neurology (ArmaGen), Immunotherapy (AnaptysBio), Metabolic/diabetes (Cebix), Dental (Novalar), Infectious disease (Nventa), Oncology (Dendreon) and Cardiovascular disease (Corvas).  He began his career as a Research Associate at the Sanford Burnham Institute in La Jolla, CA.  Derek has a BA in Molecular and Cell Biology from the University of California, Berkeley and an MBA from University of San Diego.

Jennifer Bahr-Davidson, Ph.D.

Jennifer Bahr-Davidson joined Lineage Cell Therapeutics as Vice President of Technical Operations & QA in December 2010.  Jennifer brings over 25 years of experience in CMC and quality operations for cell and gene therapies, devices, small molecules, and diagnostics.  Jennifer specializes in building quality and GMP operations teams and managing external resources to develop and manufacture investigational products. In her last position, Jennifer led various operational teams at Avigen for in-house development and production of clinical AAV vectors and external development and manufacture of oral small molecule investigational products. Prior to joining Avigen, Jennifer worked as an Associate Scientist, Rare Reagent Manufacturing at Metra Biosystems, developing and producing antigens and antibodies utilized in ELISA based clinical diagnostics kits.  Jennifer obtained her BS in Chemical Engineering from the University of Colorado, Boulder, and her MS and PhD in Chemical Engineering from Stanford University.

Charlotte Hubbert, Ph.D.

Dr. Charlotte Hubbert joined Lineage as Vice President of Corporate Development in April 2024. Dr. Hubbert has over fifteen years basic science research background and over fifteen years biotech venture investment experience across a broad range of sectors, therapeutic modalities, and stages. She has a proven ability to combine deep scientific expertise and business development acumen to identify innovative opportunities to drive both returns and impact.

Before joining Lineage, she was on the leadership team for Business Development & Strategic Alliances at NanoString Technologies. Previous to NanoString, Dr. Hubbert was Partner and head of Gates Foundation Venture Capital, a $500 million initiative at the Bill and Melinda Gates Foundation Strategic Investment Fund, where she oversaw investing in innovative technologies that supported the foundation’s programs in global health and agriculture. Notably, she led investments and served on the board of directors of Synlogic (Nasdaq: SYBX), Sera Prognostics, Lodo Therapeutics, Agtech Accelerator, Vedanta, and Vir Biotechnology (Nasdaq: VIR). Prior to joining the Bill and Melinda Gates Foundation Strategic Investment Fund. Dr. Hubbert was a vice president at H.I.G. BioVentures, investing broadly in healthcare. She began her career in early-stage biotech, investing at Accelerator Corporation, where she was part of the founding team.

Dr. Hubbert earned a B.S. in microbiology from the University of Washington and a Ph.D. in cancer biology from Duke University for which she received the prestigious Harold Weintraub Award. She did her post-doctoral work in stem cells and regenerative medicine at the Institute for Stem Cells and Regenerative Medicine at the University of Washington. Dr. Hubbert is a member of the Kauffman Society of Fellows and is a Fierce Woman in Biopharma awardee which recognizes top executives in Biopharma. She previously served on the Board of Directors of Life Science Washington, and the steering committees of the Fred Hutch Cancer Institute’s Evergreen Fund, University of Washington Innovation Roundtable and Columbia University Lab-to-Market initiative.

Dr. Hubbert currently serves on the Board of Directors of the Beckman Research Institute at the City of Hope, and is a Strategic Director at Madrona Venture Group, where she advises their growing A/ML-driven life science portfolio.

Rami Skaliter, M.Sc., Ph.D.

Rami Skaliter, M.Sc., Ph.D., is the CEO of Cell Cure Neurosciences, a majority-owned (>95%) Israeli subsidiary of Lineage. The site is focused on manufacturing and related research and development activities. Dr. Skaliter was appointed in June 2017. In his last position, Dr. Skaliter worked for ten years as the Chief Operating Officer of Quark Pharmaceuticals, a late-stage pharmaceutical company developing siRNA-based novel therapeutics. Previously, Dr. Skaliter held various corporate and research executive positions at Quark Pharmaceuticals. Dr. Skaliter obtained his B.Sc. in Biology at the Ben-Gurion University and his M.Sc. and Ph.D. in Biochemistry at the Weizmann Institute in Israel. He specialized in the biochemistry of replication and mutagenesis mechanisms. Between 1993 and 1995, prior to joining Quark, Dr. Skaliter completed a post-doctoral fellowship at Stanford University.